PI4KIIIbeta Inhibitor, BF738735 – Calbiochem

Descrição detalhada : A cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIbeta (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIalpha (IC50 = 1.7 µM) and several other lipid kinases (IC50 >10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
Sinónimos : PI4KIIIbeta Inhibitor, BF738735 - Calbiochem; 2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III beta Inhibitor, BF-738735
Fórmula molecula r: C21H19FN4O3S
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA