Monoclonal Anti-tau (Tau) antibody produced in mouse

Descrição detalhada : The antibody reacts exclusively with the chemically heterogeneous tau in both the phosphorylated and non-phosphorylated form. The antibody does not react with other MAPs or with tubulin. In immunohistochemical staining, it localizes tau along microtubules in axons, somata, dendrites and astrocytes, and on ribosomes. The antibody may be used for staining of tau in Alzheimer neurofibrillary tangles in sections of human brain tissue., The best known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is chemically heterogenous, however, limited protolysis has demonstrated that the different eletrophoretic species are closely related. Tau is immunologically distinct from the other MAPs, namely MAP1, MAP2 and MAP5. Localization studies have demonstrated that Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer's disease brain., Monoclonal Anti- ? (TAU) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. ? (TAU) proteins are a part of microtubule associated proteins (MAPs). They are densely found in neurons and in trace amounts in non-neuronal cells. In brain six isoforms of ? (TAU) proteins are present.
Sinónimos : Anti-DDPAC; Anti-FTDP-17; Anti-MAPTL; Anti-MSTD; Anti-MTBT1; Anti-MTBT2; Anti-PPND; Anti-PPP1R103; Anti-TAU; Anti-tau-40
Armazenamento : -20C
Embalagem : 1X.2ML