Akt Inhibitor II – Calbiochem

Descrição detalhada : A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38alpha/SAPK2alpha MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity., A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38alpha/SAPK2alpha MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
Sinónimos : Akt Inhibitor II - Calbiochem; SH-5
Fórmula molecula r: C29H59O10P
Armazenamento : -20C
Embalagem : 1X1MG