betaARK1 Inhibitor – CAS 24269-96-3 – Calbiochem

REF : 182200-5MG
Marca : Sigma-Aldrich
Descrição :betaARK1 Inhibitor - CAS 24269-96-3 - Calbiochem The betaARK1 Inhibitor, also referenced under CAS 24269-96-3, controls the biological activity of betaARK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Clique para mais informações
Categoria :
CAS :
Descrição detalhada : A selective inhibitor of beta-adrenergic receptor kinase 1 (betaARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit betaARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between betaARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of betaARK1 desensitize agonist-bound beta2-adrenergic receptors., A selective inhibitor of betaARK1 (beta-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
Sinónimos : betaARK1 Inhibitor - CAS 24269-96-3 - Calbiochem; beta-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
Fórmula molecula r: C12H9NO6
Armazenamento : -20C
Embalagem : 1X5MG