Aurora Kinase Inhibitor VI, ZM447439 – CAS 331771-20-1 – Calbiochem

REF : 189410-5MG
Marca : Sigma-Aldrich
Descrição :Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 >10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
Sinónimos : Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem; 4-(4-(N-Benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline
Fórmula molecula r: C29H31N5O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG