Brevetoxin PbTx-2, Ptychodiscus brevis – CAS 79580-28-2 – Calbiochem

Descrição detalhada : Lipid-soluble polyether neurotoxin that binds to Na+ channels on nerves and muscles causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel., Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models. The excitatory action on nerve and muscle membranes is responsible for a wide spectrum of toxic effects, including massive transmitter release from nerve endings, muscle fasiculation, and ventricular fibrillation. The excitatory action is due to opening of the Na+ channels. The toxin does not bind either to the TTX or to the aconitine/veratridine sites.
Sinónimos : Brevetoxin PbTx-2, Ptychodiscus brevis - CAS 79580-28-2 - Calbiochem; Brevetoxin B, GbTx-2
Fórmula molecula r: C50H70O14
Armazenamento : -20C
Embalagem : 1X100UG