Calpain Inhibitor VI – CAS 190274-53-4 – Calbiochem

Descrição detalhada : A potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and alpha-spectrin in cultured lenses., A cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and cathepsin L (IC50 = 1.6 nM). Reduces betaFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and alpha-spectrin in cultured rat lenses.
Sinónimos : Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem; N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
Fórmula molecula r: C17H25FN2O4S
Armazenamento : -20C
Embalagem : 1X5MG