Cdc25 Inhibitor IV, NSC 95397 – CAS 93718-83-3 – Calbiochem

Descrição detalhada : A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Sinónimos : Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem; (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
Fórmula molecula r: C14H14O4S2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG