beta-Catenin/Tcf Inhibitor, FH535 – CAS 108409-83-2 – Calbiochem

Descrição detalhada : A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/beta-catenin (>=80% inhibition at 15 µM in beta-catenin/Tcf-dependent cellular reporter assays) and PPARgamma/delta (>=30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARgamma-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks beta-catenin/PPARgamma interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action., A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/beta-catenin (>=80% inhibition at 15 µM in beta-catenin/Tcf-dependent cellular reporter assays) and PPARgamma/delta (>=30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARgamma-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks beta-catenin/PPARgamma interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
Sinónimos : beta-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem; N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide, Wnt Pathway Inhibitor IX
Fórmula molecula r: C13H10Cl2N2O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG