CXCR7 Agonist, VUF11207 – Calbiochem

REF : 239824-10MG
Marca : Sigma-Aldrich
Descrição :CXCR7 Agonist, VUF11207 - Calbiochem The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Descrição detalhada : A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of beta-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and beta-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in beta-arrestin2 is recruited to the active receptor.
Sinónimos : CXCR7 Agonist, VUF11207 - Calbiochem; (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
Fórmula molecula r: C27H35FN2O4
Armazenamento : -20C
Embalagem : 1X10MG