5ʹ-Deoxy-5ʹ-methylthioadenosine – CAS 2457-80-9 – Calbiochem

Descrição detalhada : A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells., A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
Sinónimos : 5?-Deoxy-5?-methylthioadenosine - CAS 2457-80-9 - Calbiochem; MTA, MeSAdo
Fórmula molecula r: C11H15N5O3S
Armazenamento : -20C
Embalagem : 1X50MG