Dkk-1 Inhibitor, WAY-262611, HCl – Calbiochem

Descrição detalhada : A 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Sinónimos : Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem; (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
Fórmula molecula r: C20H22N4 · xHCl
Armazenamento : -20C
Embalagem : 1X10MG