STAT3 Inhibitor XVI – Calbiochem

REF : 407625-5MG
Marca : Sigma-Aldrich
Descrição :STAT3 Inhibitor XVI - Calbiochem The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.
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Descrição detalhada : A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50 = 15 µM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30 µ:M and 30-100 µM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level.
Sinónimos : STAT3 Inhibitor XVI - Calbiochem; IL-6 Inhibitor
Fórmula molecula r: C21H22N2O3S3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG