JNK Inhibitor I, (L)-Form, Cell-Permeable – Calbiochem

Descrição detalhada : A cell-permeable, biologically active peptide consisting of a carboxyl terminal sequence derived from the JNK-binding domain (JBD) and an amino terminal peptide containing the HIV-TAT48-57 sequence. Blocks c-Jun NH2-terminal kinase (JNK) signaling by preventing the activation of the transcription factor c-jun (IC50 ~ 1 µM). This effect appears to be due to inhibition of phosphorylation of the activation domains of JNK. Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB) that is shown to be critical for interaction with JNK linked to the 10-amino acid HIV-TAT48-57 sequence as a carrier peptide and two proline residues as spacer. Inhibits IL-1beta-induced c-jun and c-fos expression in insulin secreting betaTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no effect on either ERK 1/2 or p38 activities., A cell-permeable, biologically active peptide consisting of a carboxyl- terminal sequence derived from the JNK-binding domain (JBD) and an amino-terminal peptide containing the HIV-TAT48-57 sequence that imparts cell-permeability. Blocks the activation domain of c-Jun NH2-terminal kinase (JNK) and prevents the activation of the transcription factor c-Jun (IC50 ~1 µM). Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB), which is critical for interaction with JNK.The peptide is covalently linked to the 10-amino acid HIV-TAT48-57 sequence that acts as a carrier peptide and to two proline residue spacers. Inhibits IL-1beta-induced c-Jun and c-fos expression in insulin secreting betaTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no significant effect on the activities of ERK1, ERK2, or p38.
Sinónimos : JNK Inhibitor I, (L)-Form, Cell-Permeable - Calbiochem; c-Jun NH?-terminal kinase, SAPK Inhibitor I, (L)-JNKI1, ( L)-HIV-TAT?????-PP-JBD??, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH₂
Fórmula molecula r: C168H293N67O42
Armazenamento : -20C
Embalagem : 1X1MG