JAK3/GSK-3beta/PKCalpha Inhibitor – CAS 1260181-14-3 – Calbiochem

REF : 420148-5MG
Marca : Sigma-Aldrich
Descrição :JAK3/GSK-3beta/PKCalpha Inhibitor - CAS 1260181-14-3 - Calbiochem The JAK3/GSK-3beta/PKCalpha Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3beta/PKCalpha. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3beta, JAK3, PKCalpha and PKCtheta (IC50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over 40-kinases, including JAK1, JAK2 and Tyk2 (IC50 = 1.017, 2.55 and 8.055 µM, respectively). Shown to efficiently block interleukin stimulated STAT5 phosphorylation and T cell costimulation (IC50 = 0.525, 1.294 and 0.689 µM in IL15-MO7, IL2-CTLL and TCR/CD28-Jurkat cells, respectively).
Sinónimos : JAK3/GSK-3beta/PKCalpha Inhibitor - CAS 1260181-14-3 - Calbiochem; 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione, JAK3 Inhibitor XII, NIBR3049; JAK3 Inhibitor XII, NIBR3049, 3-(5-(4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1-yl)-2-trifluoromethyl-phenyl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione
Fórmula molecula r: C27H25F3N4O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG