MMP-12 Inhibitor, MMP408 – CAS 1258003-93-8 – Calbiochem

Descrição detalhada : A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC >5 microM), TACE (IC >25 microM), and MMP-1/7 (IC >6 microM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.)., A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC >5 microM), TACE (IC >25 microM), and MMP-1/7 (IC >6 microM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
Sinónimos : MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem; (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
Fórmula molecula r: C19H20N2O7S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG