MK-2 Inhibitor III – CAS 1186648-22-5 – Calbiochem

REF : 475864-5MG
Marca : Sigma-Aldrich
Descrição :MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Clique para mais informações
Categoria :
CAS :
Descrição detalhada : A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-alpha production in U937 cells (IC50 = 4.4 µM)., A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-alpha production in U937 cells (IC50 = 4.4 µM).
Sinónimos : MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem; 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
Fórmula molecula r: C21H16N4O · xH2O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG