PAD Inhibitor, Cl-amidine – Calbiochem

Descrição detalhada : A cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo. Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.
Sinónimos : PAD Inhibitor, Cl-amidine - Calbiochem; N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide
Fórmula molecula r: C16H20ClF3N4O4
Armazenamento : -20C
Embalagem : 1X10MG