Pam₃Cys-Ser-(Lys)₄, Hydrochloride

Descrição detalhada : A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-alpha, superoxide, and NO. Promotes the translocation of NF-kappaB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2)., A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-alpha, superoxide and NO. Promotes the translocation of NF-kappaB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.
Sinónimos : Pam?Cys-Ser-(Lys)?, Hydrochloride; (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys?-OH, 3HCl, P?CSK?, 3HCl, Pam?Cys-SK?, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
Fórmula molecula r: C81H156N10O13S · 3HCl
Armazenamento : -20C
Embalagem : 1X2MG