Phorbol-12,13-dibutyrate – CAS 37558-16-0 – Calbiochem

Descrição detalhada : Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds., Strong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
Sinónimos : Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem; PDBu, PKC Activator II
Fórmula molecula r: C28H40O8
Armazenamento : -20C
Embalagem : 1X1MG