Phorbol-12-myristate-13-acetate – CAS 16561-29-8 – Calbiochem

Descrição detalhada : Extremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester., Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
Sinónimos : Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem; PMA, TPA, PKC Activator I; TPA, PMA, PKC Activator I
Fórmula molecula r: C36H56O8
Armazenamento : -20C
Embalagem : 1X1MG