GAK Inhibitor – Calbiochem

Descrição detalhada : A cell-permeable isothiazolopyridine based compound that acts as a high-affinity binding, reversible and ATP-competitive inhibitor of cyclin G associated kinase (GAK; Kd = 8.3 nM). Displays moderate to excellent selectivity over Kit, PDGFRbeta, Flt3, Mek5 & PDGFRalpha (Kd = 29, 70, 110, 150 & 220 nM, respectively) in a 456-kinase profiling. Shown to dose-dependently disrupt both HCV entry & assembly and efficiently arrest HCV infection (EC50 = 2.55 & 3.6 µM in HCVcc- & HCVpp-infected Huh-7.5 cells, respectively; CC50 = 23.27 µM in HCVcc-infected Huh-7.5 cells). Significantly inhibits intracellular & extracellular infectivity (EC50 = 1.64 & 2.13 µM, respectively) and AP2M1 phosphorylation. Exerts no effect on HCV RNA replication.
Sinónimos : GAK Inhibitor - Calbiochem; Cyclin G Associated Kinase Inhibitor, Auxilin 2 Inhibitor
Fórmula molecula r: C19H21N3O4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA