Anti-phospho-c-Abl (pTyr412) antibody produced in rabbit

Descrição detalhada : c-Abl is a proto-oncogene of the Src family of non-receptor tyrosine kinases. It is a cellular homologue of Ablelson murine leukemia virus, and is implicated in many important cellular processes and tumorigenesis. In mammalian cells, c-Abl is expressed ubiquitously but its localization within a cell depends on the cell type and the environmental signals. c-Abl has distinct SH2 and SH3 domains that indicate high affinity for tyrosine and proline residues. Complete activation of c-Abl requires phosphorylation at two tyrosine residues at 412 and 245. Some of the downstream targets of c-Abl identified are ATM, DNA-PK, BRCA1, and transcription factors p73 and RFX1. Several reports implicate c-Abl in Apoptosis, DNA repair, T cell development and neuronal development. Anti-phospho-c-Abl [pTyr412] specifically recognizes c-Abl phosphorylated at tyrosine 412 (~140-150 kDa). The antibody detects human c-Abl. Mouse c-Abl (100% homology) and rat c-Abl is expected to cross react.
Sinónimos : Anti-ABL; Anti-BCR-ABL; Anti-CHDSKM; Anti-JTK7; Anti-bcr/abl; Anti-c-ABL; Anti-c-ABL1; Anti-p150; Anti-v-abl
Armazenamento : -20C
Embalagem : 1X1VL