Rac1 Inhibitor – CAS 1177865-17-6 – Calbiochem

REF : 553502-10MG
Marca : Sigma-Aldrich
Descrição :Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC?? ~50 µM).
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Descrição detalhada : A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 muM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50 = 50 mM and 64 mM, respectively).
Sinónimos : Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem; NSC23766
Fórmula molecula r: C24H38Cl3N7
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG