REV-ERBalpha Antagonist, SR8278 – Calbiochem

Descrição detalhada : A cell-permeable REV-ERB antagonist that inhibits REV-ERBalpha transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Sinónimos : REV-ERBalpha Antagonist, SR8278 - Calbiochem; SR8278SR 8278
Fórmula molecula r: C18H19NO3S2
Armazenamento : -20C
Embalagem : 1X5MG