InSolution beta-Secretase Inhibitor IV – CAS 797035-11-1 – Calbiochem

REF : 565794-500UG
Marca : Sigma-Aldrich
Descrição :InSolution beta-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem The InSolution beta-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of beta-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
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Descrição detalhada : A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.
Sinónimos : InSolution beta-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem; N-(1 S, 2 R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-N?-((1 R)-1-phenylethyl)isophthalamide
Fórmula molecula r: C31H38N4O5S
Armazenamento : -70C
Embalagem : 1X500UG