Tpl2 Kinase Inhibitor – CAS 871307-18-5 – Calbiochem

REF : 616373-1MG
Marca : Sigma-Aldrich
Descrição :Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-alpha production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
Sinónimos : Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
Fórmula molecula r: C21H14ClFN6
Armazenamento : -20C
Embalagem : 1X1MG