InSolution TGF-beta RI Kinase Inhibitor VI, SB431542 – CAS 301836-41-9 – Calbiochem

Descrição detalhada : A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-beta in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 >=10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).
Sinónimos : InSolution TGF-beta RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
Fórmula molecula r: C22H16N4O3 · 2H2O
Armazenamento : -20C
Embalagem : 1X5MG