Transglutaminase 2 Inhibitor, ZDON – Calbiochem

REF : 616467-5MG
Marca : Sigma-Aldrich
Descrição :Transglutaminase 2 Inhibitor, ZDON - Calbiochem A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC?? = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2.
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Descrição detalhada : A cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
Sinónimos : Transglutaminase 2 Inhibitor, ZDON - Calbiochem; Z-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
Fórmula molecula r: C31H45N7O9
Armazenamento : -20C
Embalagem : 1X5MG