TRPV4 Antagonist I, RN-1734 – CAS 946387-07-1 – Calbiochem

REF : 616520-10MG
Marca : Sigma-Aldrich
Descrição :TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Descrição detalhada : A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4alpha-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 µM)., A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4alpha-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 µM).
Sinónimos : TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem; 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734; RN1734, 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I
Fórmula molecula r: C14H22Cl2N2O2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG