Anti-Actin, alpha-Smooth Muscle – FITC antibody, Mouse monoclonal

Descrição detalhada : The antibody (also known as anti-alpha-Sm-1) is specific for the single isoform of alpha-smooth muscle actin. It reacts specifically with alpha-smooth muscle actin in immunoblotting assays and labels smooth muscle cells in frozen or formalin-fixed, paraffin-embedded tissue sections., ?-smooth muscle actin, a smooth muscle cell-specific protein, is also known as aortic smooth muscle or a smooth muscle actin (?-SMA, SMactin, ?-SM-actin, ASMA). It belongs to the actin family.It is predominantly found in cells of the smooth muscle lineages. It has been reported that ?-smooth muscle actin was also found in certain non-muscle cells, in particular fibroblasts i.e. myofibroblasts. Actin, a conserved eukaryotic protein, is the major cytoskeletal component and is expressed as six different isoforms in mammals and birds. It is mapped to human chromosome 10q23.31.The antibody reacts with normal and neoplastic, human vascular and visceral smooth muscle cells. It reacts with normal myoepithelial cells, pericytes, eye lens cells, hair follicle cells and certain stromal cells in the intestine, testis, lymphoid organs, liver, ovary and bone marrow. The antibody also reacts with stromal myofibroblasts in hypertrophic scars, and in neoplastic tissues. ?-smooth muscle actin is transiently co-expressed with sarcomeric ?-actin during myogenesis in chicken and rat embryos. It was also found in the ventricular conducting tract of adult mammalian heart.
Sinónimos : Monoclonal Anti-Actin, alpha-Smooth Muscle; SMA
Armazenamento : -20C
Embalagem : 1X.2ML