Fmoc-Asp(O-2-PhiPr)-OH

Descrição detalhada : Quasi-orthogonally-protected Asp derivative.The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS [2] or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Asp(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.This derivative has also been used in solution to prepare bicyclic helix initiating peptides [3].The product number for this product was previously 04-12-1200.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
Sinónimos : Fmoc-Asp(O-2-PhiPr)-OH; N-alpha-Fmoc-L-aspartic acid beta-2-phenylisopropyl ester
Fórmula molecula r: C28H27NO6
Armazenamento : 15-25C
Embalagem : 1X1EA