Anti-IkappaBalpha Antibody

Descrição detalhada : IKK beta (IkappaB Kinase, IKKbeta, I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. IkappaB Kinase (IKK) complex is a critical component in NFkappaB regulation. In a majority of unstimulated cells, the NFkappaB transcription factors exist in their inactive form and are retained in the cytoplasm by the bound inhibitory IkappaB proteins. For NFkappaB to become activated, it must first disassociate from the inhibitor IkappaB. This occurs via the serine phosphorylation of IkappaB on Ser32 and Ser36. Post receptor stimulation, most notably by TNFalpha, NIK, a serine/threonine kinase, activates and phosphorylates IKKalpha and IKKbeta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates, which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK-1. IKK then binds to and phosphorylates IkappaBalpha on the two serine residues. This phosphorylation marks IkappaB for ubiquination and destruction by the proteosome. This frees the NFkappaB complex and allows it to translocate to the nucleus.
Armazenamento : -20°C
Embalagem : 1X1EA