Anti-SOX1 Antibody

Descrição detalhada : Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to beta-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.
Sinónimos : SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA