Milli-Mark(R) Anti-CD79alphacy-PE Antibody, clone HM57

Descrição detalhada : CD79 is a disulphide-linked transmembrane heterodimer with a molecular mass of 82-95 kDa belonging to the immunoglobulin superfamily. It comprises the two glycoproteins, CD79alpha, with a molecular mass of 40-45 kDa, and CD79beta, with a molecular mass of 37 kDa. CD79 is non-covalently associated with surface Ig, forming the B-cell receptor complex, which is required for antigen recognition. The expression of CD79 is largely restricted to B-lineage cells (Pilozzi,1998). In precursor B cells, the CD79 protein chains are already expressed in the cytoplasm (CyCD79). Surface expression of CD79 begins at the pro-B cell stage and persists throughout the B-cell differentiation. CD79alpha is more strongly expressed by B cells in the follicular mantle zone than by germinal centre B cells, suggesting that activation of mature B cells downregulates CD79 expression. CD79 expression ceases around the onset of plasma cell differentiation, with only a proportion of plasma cells containing CD79 (Comans-Bitter, 1997)(Nakamura, 1997). The HM57 antibody was clustered as Anti-CD79alphacy at the Fifth International Workship on Human Leucocyte Differentiation Antigens (Engel, 1995).
Sinónimos : B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Surface IgM-associated protein, Membrane-bound immunoglobulin-associated protein
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA