Anti-Fibroblast activation protein alpha (FAP) Antibody

Descrição detalhada : Fibroblast activation protein alpha (FAP), also known as Seprase, is a 97 kDa, type II cell surface glycoprotein belonging to the serine protease family. Although FAP is considered fibroblast specific, it is not found in normal healthy fibroblasts. FAP is most commonly found in stromal, tumor fibroblasts, and is likely involved in ECM pericellular proteolysis, endothelial cell migration and invasion into the ECM. The presence of FAP in human epithelial carcinoma is increased, particularly in breast, colorectal, lung, and ovarian carcinomas. FAP is also transiently observed in developing cells, or in tissues that are undergoing wound healing or suffering from chronic inflammatory conditions. Due to its specific distribution both to tumor fibroblasts and to inflammed tissue, FAP makes a promising target for research in tumor-stromal studies and in therapeutic studies.
Sinónimos : fibroblast activation protein, alpha, fibroblast activation protein, alpha subunit, integral membrane serine protease, seprase, 170 kDa melanoma membrane-bound gelatinase, FAP
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA