Anti-JMJD8 Antibody

Descrição detalhada : Covalent modification of histones plays critical role in regulating chromatin structure and transcription. JMJD8 is one member of the family of JmjC domain-containing histone demethylation (JHDM) enzymes. These proteins remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. While two isoforms of JMJD8 have been described, further study is still required to clarify the roles and mechanisms of JMJD8 among other JHDM protein family members.
Sinónimos : JMJD, JmjC domain-containing protein 8, Jumonji domain-containing protein 8
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA