Anti-Amyloid, beta 1-40, abeta Antibody

Descrição detalhada : Amyloid beta 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid beta 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer's disease. Previous studies have reported that expression of amyloid beta 1-40 increases in Alzheimer's disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.
Sinónimos : Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, 1.N-APP2.Soluble APP-alpha, S-APP-alpha3.Soluble APP-beta, S-APP-beta4.C995.Beta-amyloid protein 42, Be
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA