Anti-FcepsilonRI alpha subunit Antibody

Descrição detalhada : The allergic reaction is mediated through the IgE high affinity receptor (FcepsilonRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FcepsilonRI receptor complexes causes the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FcepsilonRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. The a-chain is primarily involved with the binding of IgE, but the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FcepsilonRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.
Sinónimos : High affinity immunoglobulin epsilon receptor subunit alpha, Fc-epsilon RI-alpha, FcERI, IgE Fc receptor subunit alpha
Armazenamento : -20°C
Embalagem : 1X1EA