Anti-MATK Antibody, clone 9D7

Descrição detalhada : Megakaryocyte-associated tyrosine-protein kinase (MATK), or alternatively CSK homologous kinase (CHK), Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, is an important kinase in hematopoietic signal transduction in blood cells as well as in other cells such as neurons and T cells. As its name would imply, MATK was first associated with megakaryocytes, the cells that give rise to platelets. MATK is able to phosphorylate and inactivate Src family kinases and may play a role in the regulation of proliferation of some cells such as T cells. In the nervous system MATK (called CHK in the older literature) plays a distinct role in the development of the CNS. MATK was found to be expressed in a developmental manner and expressed not only in developing neurons but also astrocytes and oligodendrocytes, but not in any of the associated tumors from these cell types, possibly indicating that it is the loss of expression of MATK activity that impacts tumorigenesis. EMD-Millipore's Anti-MATK monoclonal antibody has been tested in western blot using K562 cell lysates and in flow cytometry using permeabilized K562 cells in culture.
Sinónimos : Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK
Armazenamento : -20°C
Embalagem : 1X1EA