Anti-CKAP4 Antibody, clone 9C4.4

Descrição detalhada : Cytoskeleton-associated protein 4, also known as 63-kDa cytoskeleton-linking membrane protein or Climp-63 or p63, and encoded by the gene CKAP4, is an integral membrane protein that links the endoplasmic reticulum (ER) to microtubules. The binding of CKAP4 is dependent upon its phosphorylation state: dephosphorylated CKAP4 binds microtubules and phosphorylated CKAP4 does not bind microtubules. CKAP4 is localized to the endoplasmic reticulum membrane and plasma membrane; CKAP4 is also found in the cytoplasm and perinuclear regions upon APF stimulation. CKAP4 is expressed is a wide variety of cell types and tissues and CKAP4 appears to be critical for antibiotic cytotoxicity for certain drugs like Gentamycin which bind the drug and cause CKAP4 to dimerize and malfunction.
Sinónimos : Cytoskeleton-associated protein 4, 63-kDa cytoskeleton-linking membrane protein, Climp-63, p63
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA