Anti-MAP17 Antibody, clone 165C

Descrição detalhada : The protein named PDZK1-interacting protein 1 or alternatively 17kDa membrane-associated protein DD96 or MAP17 and encoded by the human gene named PDZK1IP1 or MAP17 is a highly unusual protein being naturally expressed only in a single epithelial cell population found in the proximal tubular epithelial cells. However, MAP17 is expressed in cancerous tissue of the kidney, colon, lung and breast. MAP17 expression in cancers causes an increase in reactive oxygen species production and tumorigenesis in cancerous tissues. These factors are mediated though MAP17's PDZ-binding domain because disruption of this sequence by point mutations abolishes the ability of MAP17 to enhance ROS production and tumorigenesis. MAP17 also often serves as a cancer cell marker to distinguish tumor margins and tumorigenesis potential. MAP17 is a membrane bound protein and is thought to be a putative oncogene but its exact function in normal cells is still being researched.
Sinónimos : PDZK1-interacting protein 1, 17 kDa membrane-associated protein, Protein DD96
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA