Anti-alpha-Actinin (Sarcomeric) antibody, Mouse monoclonal

Descrição detalhada : ?-Actinin is a 100kDa actin-binding protein that is found in muscle as well as non-muscle cells. In smooth muscles, ?-actinin is present in dense bodies and plaques whereas in normal skeletal muscles, it is associated with z-discs that define muscle sarcomeres. The gene encoding ?-actinin is mapped to the human chromosome 11q13.2. ?-Actinin belongs to the spectrin protein superfamily.?-Actinin dimerizes in an antiparallel fashion via interaction of the central rod domains. Four isoforms are found in human and mice. ?-actinin-1 is ubiquitously expressed and located primarily in focal adhesions, whereas ?-actinin-4 is present in certain membrane ruffles and seems to play a role in endocytosis and tumor cell motility.ACTN1 (?-actinin-1) and ACTN4 (?-actinin-4) encodes non-muscle proteins, while ACTN2 (?-actinin-2) and ACTN3 (?-actinin-3) encodes muscle proteins.Monoclonal Anti-?-Actinin (Sarcomeric) shows wide reactivity, as it binds to human, bovine, pig, sheep, rabbit, goat, hamster, cat, rat, mouse, dog, chicken, lizard, snake, frog and fish ?-actinin.
Sinónimos : Anti-ACTN2; Anti-Actinin alpha2; Anti-CMD1AA; Anti-MGC107582; Anti-1110008F24Rik; Sarcomeric Alpha Actinin Antibody; Sarcomeric Alpha Actinin Antibody - Anti-alpha-Actinin (Sarcomeric) antibody, Mouse monoclonal
Armazenamento : -20C
Embalagem : 1X100UL