TPC-1 Human Papillary Thyroid Carcinoma Cell line

Descrição detalhada : TPC-1 is a widely published and well-characterized cell line isolated from a papillary thyroid carcinoma of a female patient (6). The genome of TPC-1 contains the RET/PTC1 rearrangement found in approximately 20% of sporadic papillary carcinomas in adults (2). TPC-1 harbors a silent polymorphism in H-RAS, and is wild-type for sequences of BRAF, CNBB1, EGFR, K-RAS, RAF-1, PI3K, and TRHB (3). TPC-1 cells produce thyroglobulin (Tg) as well as expressing the thyroid differentiation marker PAX8 and the tumor progression factor podoplanin (4). In addition, TPC-1 has been utilized as an in vitro model for human cytomegalovirus latency, a potential contributor for certain human cancers (5). The TPC-1 cell line is thus an excellent system for investigating mechanisms of thyroid carcinogenesis., Thyroid cancer is the most prevalent endocrine carcinoma, with a rapidly increasing occurrence in many countries. Human models of differentiated thyroid cancer are highly valuable for assessing the pathways and mechanisms that contribute to thyroid carcinogenesis. References:1. Davies L, Welch HG (2006). Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295(18): 2164-2167.2. Pilli T, et al. (2009). Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid 19(12): 1333-1342.3. Meireles AM, et al. (2007). Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid 17(8): 707-715.4. Rudzińska M, et al. (2014). The role of podoplanin in the biology of differentiated thyroid cancers. PLoS One 9(5): e96541.5. Tanaka J, et al. (1987). Establishment and biological characterization of an in vitro human cytomegalovirus latency model. Virology 161(1): 62-72.6. Ishizaka Y, et al. (1989). Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line. Jpn J Cancer Res 80(12): 1149-1152.
Sinónimos : TPC1; TPC1
Armazenamento : -140C Degree Freezer
Embalagem : 1X1EA