Anti-Interferon-alpha2 Antibody, clone ST254

Descrição detalhada : This Anti-Interferon-alpha2 Antibody, clone ST254 (Ascites Free) is validated for use in Western Blotting, Affinity Binding Assays, ELISA and Neutralizing., Interferon alpha-2 (UniProt P01563; also known as IFN-alpha-2, Interferon alpha-A, LeIF A) is encoded by the IFNA2 (also known as IFNA2A, IFNA2B, IFNA2C) gene (Gene ID 3440) in human. Interferons (IFNs) are cytokines whose prouction and release by host cells are induced in the presence of pathogens (e.g. viruses, bacteria, parasites) and tumor cells. Originally named for their ability to interfere with viral replication, IFNs mediate the activation of immune cells, such as natural killer cells and macrophages, and increase host defense by up-regulating antigen presentation by boosting the expression of major histocompatibility complex (MHC) antigens. More than twenty distinct IFN genes and proteins have been identified and classified into three main types. Type I IFNs (IFN-alpha, IFN-beta, IFN-epsilon, IFN-kappa, and IFN-omega) exert their function via binding IFN-alpha/beta receptor (encoded by the IFNAR1 and IFNAR2 gene, respectively). IFN-gamma is the only known type II IFN, it is released by type 1 T helper cells and binds IFN-gamma receptor (encoded by the IFNGR1 and IFNGR2 gene, respectively). Type III IFNs signal through a receptor complex consisting of IL10R2 (CRF2-4) and IFNLR1 (CRF2-12).
Sinónimos : Interferon alpha-2, IFN-alpha-2, Interferon alpha-A, LeIF A, Interferon-alpha2
Armazenamento : -20°C
Embalagem : 1X1EA