Anti-phospho-Amyloid beta (Ser8) Antibody, clone 1E4E11

Descrição detalhada : Amyloid beta A4 protein (UniProt P05067; also known as ABPP, Alzheimer disease amyloid protein, Amyloid precursor protein, APP, APPI, Cerebral vascular amyloid peptide, CVAP, PN-II, PreA4, Protease nexin-II) is encoded by the APP (also known as A4, AD1) gene (Gene ID 351) in human. Amyloid precursor protein (APP) is initially produced with a signal peptide sequence (a.a. 1-17), the removal of which yields the mature protein with a large extracellular portion (a.a. 18-699), followed by a transmembrane segment (a.a. 700-723) and a cytoplasmic (a.a. 724-770) tail. APP can be further processed by the alpha-, beta-, and gamma-secretases in two alternative processing pathways. In the non-amyloidogenic pathway, APP is first cleaved by the plasma membrane-localized alpha-secretase to generate an N-terminal extracellular sAPPalpha fragment (a.a. 18-687) and a membrane-bound C-terminal fragment C83 (CTFalpha), which can be further cleaved by gamma-secretase to produce a non-toxic small peptide p3 and a cytoplasmic APP intracellular domain (AICD). In the amyloidogenic pathway, APP undergoes beta-cleavage in BACE-1 (beta-site APP-cleaving enzyme)-enriched endosomes to generate an N-terminal extracellular sAPPbeta fragment (a.a. 18-671) and a membrane-bound C-terminal fragment C99 (CTFbeta). Subsequent cleavage of C99 by gamma-secretase releases the amyloid beta peptides, Abeta1-42 (672-713) & Abeta1-40 (672-711), and AICD. Abeta accumulation in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer's disease (AD). Abeta Ser8 phosphorylation is shown to promote Abeta aggregation into oligomeric and fibrillar assemblies and to prevent Abeta proteolytic clearance by certain proteases.
Sinónimos : Abeta peptide, Ser8 phosphorylated, Abeta peptide, Ser8 phosphorylated, Amyloid beta peptide, Ser8 phosphorylated, Abeta1-40, Ser8 phosphorylated, Abeta1-42, Ser8 phosphorylated, Abeta1-40, Ser8 phosphorylated, Abeta1-42, Ser8 phosphorylated
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA