Anti-Misu/NSun2 Antibody

Descrição detalhada : Misu/NSun2, also known as tRNA (cytosine(34)-C(5))-methyltransferase, Myc-induced SUN domain-containing protein (MISU), NOL1/NOP2/Sun domain family member 2, Substrate of AIM1/Aurora kinase B, tRNA (cytosine-5-)-methyltransferase, or tRNA methyltransferase 4 homolog (hTRM4), and encoded by the gene NSUN2/SAKI/TRM4, is a RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Misu/NSun2 methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Functionally Misu/NSun2 acts downstream of Myc to regulate epidermal cell growth and proliferation, and Misu/NSun2-mediated cytosine-5 methylation of vault noncoding RNA helps to determine the processing of them into regulatory small RNAs, and Misu/NSun2 also plays a critical role in gene expression. Interestingly too, Misu/NSun2 is required for proper spindle assembly and chromosome segregation, which is independent of its methyltransferase activity. Misu/NSun2 is localized in the nucleus and nucleolus during rest but during cytokinesis it can be localized in the spindle. Mutations are associated with mental retardation.
Sinónimos : tRNA (cytosine(34)-C(5))-methyltransferase, Myc-induced SUN domain-containing protein, Misu, NOL1/NOP2/Sun domain family member 2, Substrate of AIM1/Aurora kinase B, tRNA (cytosine-5-)-methyltransferase, tRNA methyltransferase 4 homolog, hTrm4
Armazenamento : -20°C
Embalagem : 1X1EA