Anti-dimethyl Histone H2B Antibody (Pro1)

Descrição detalhada : Histone H2B is one of four histones that form a core octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability; and consequently, transcription, and DNA replication and repair. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine residues by a family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide transcriptional complexes, for example, with access to DNA, potentially resulting in increased gene transcription. Lysine 120 of H2B (H2BK120) undergoes acetylation (by p300/CBP) and ubiquitination. Acetylation occurs first and is required for subsequent mono-ubiquitination. H2BK120 may function as a marker of "pre-active" chromatin, and is part of a complex regulatory system involving multiple histone modifications.
Sinónimos : Histone H2B type 1-C/E/F/G/, H2Bme2P1, Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, Histone H2B.k, H2B.l, H2B/l
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA