beta-Glucuronidase

Descrição detalhada : beta-D-Glucuronoside glucuronosohydrolase, Glucuronidation is one of the basic principles of metabolism. Many substances presented to the human body undergo metabolic processing that includes conjugation with glucuronic acid by UDP-glucuronosyltransferases (UGTs). This enzyme catalyzes the transfer of a glucuronyl group to many biological and pharmacologically active endogenous and exogenous molecules. Glucuronide is in general, more soluble, less toxic, and more easily excreted by the human body compared to the original molecule. To analyze these drug conjugates that are present in body fluids, such as urine and plasma, deconjugation of the glucuronide is necessary.Substances used for doping are conjugated with glucuronides, which means that effective doping analysis relies very often on the enzymatic cleavage of conjugated drug molecules by β-glucuronidase.Enzyme CharacteristicsThe E. coli β-glucuronidase enzyme is essentially free of sulfatase activity and is especially efficient in cleaving steroid and benzodiazepine conjugates.β-D-Glucuronoside glucuronosohydrolaseEC 3.2.1.31
Sinónimos : beta-D-Glucuronoside glucuronosohydrolase; glucuronidase
Armazenamento : 2-8C
Embalagem : 1X1EA