NMDA Antagonist XI, N1-dansyl-spermine – Calbiochem

Descrição detalhada : An N-sulfonyl-polyamine that acts as a potent and more specific antagonist of NMDA receptors expressed in Xenopus oocytes (IC50 = 310, 340 nM in NR1/NR2A and NR1/NR2B, respectively). The inhibition appears to be voltage-dependent and is non-competitive with respect to glutamate and glycine. Exhibits about 50-fold greater selectivity over NR1/NR2C and NR1/NR2D receptors (IC50 = 16 and 13 µM, respectively). Also shown to block c-AMP-dependent, calmodulin-activated phosphodiesterase (IC50 = 58 µM) and diminishes the induction of ornithine decarboxylase. At higher concentration (˜100 µM) it is shown to reduce spontaneous epileptiform activity in mouse cortical slices.
Sinónimos : NMDA Antagonist XI, N1-dansyl-spermine - Calbiochem; NMDA channel blocker, N1-dansyl-spermine, N1-DnsSpm
Fórmula molecula r: C22H37N5O2S · 3HCl
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA